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6 Medications That Could Be Damaging Your Ears

Before starting a medicine classified as ototoxic, Lustig recommends getting a baseline hearing test and balance assessment, and then going for regular testing during treatment. That can help you and your doctor identify any hearing-related side effects early, since medicines often impact high frequency hearing first, so you might not notice the change without a hearing test.

Here are some common medications linked to hearing loss and what you need to know about this potentially life-altering side effect.

1. Over-the-counter pain relievers

Because painkillers such as aspirin, acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) like Advil and Motrin are widely available without a prescription, many patients take them regularly and assume that they are harmless. In fact, about 1 in 3 Americans takes a store-bought pain medication every day, according to a 2022 survey.

However, research indicates that over-the-counter pain relievers can contribute to both hearing loss and tinnitus, especially if they’re used for two or more days per week, says Sharon Curhan, an epidemiologist at Brigham and Women’s Hospital and Harvard Medical School and author of several studies on the connection.

In a 2012 study that followed more than 62,000 women, Curhan discovered that frequent use of acetaminophen or NSAIDs, even in typical doses, was linked to an up to 24 percent higher risk of developing hearing loss.  In men, a similar study demonstrated that regular use — two or more times per week — of acetaminophen, NSAIDs and aspirin are all associated with a higher risk of hearing loss.

Another large study, the Epidemiology of Hearing Loss Study, found that among adults who already had hearing loss, NSAID use was associated with a 45 percent higher risk of progression of their hearing loss.

Researchers speculate that the medications may reduce blood flow to the cochlea, an organ in the inner ear that helps with hearing.

“The overarching message from these findings is that even though these analgesics are widely available without a prescription, these are still medications and there are potential side effects,” Curhan says. “For anyone who is considering taking these types of medications regularly, it is advisable to consult with a health-care professional to discuss the risks and benefits and to explore whether there are alternatives to using medication.”

Fortunately, frequent use of low-dose aspirin (100 mg or less) has not been linked to hearing-related side effects. Many older adults take a low dose of the drug daily to prevent cardiovascular disease.

2. Aminoglycoside antibiotics

Some of the most damaging medications to hearing are a class of antibiotics called aminoglycosides, Lustig says. Available in pill form, as well as intravenously, they are believed to damage the sensory cells inside your ear needed for balance and hearing.

One aminoglycoside, called gentamicin, is often administered intravenously in the hospital to fight severe bacterial infections, such as a bone or an organ infection. Other drugs in the class also include “micin” or “mycin” at the end, such as streptomycin, neomycin, kanamycin and tobramycin.

Studies show more than 50 percent of patients who require multiple rounds of intravenous aminoglycosides may experience hearing loss. Even at recommended dosages, taking them “can result in rapid, profound, and irreversible hearing loss,” according to one review study. That study’s authors found that a single dose can result in permanent hearing loss in patients with a certain genetic mutation.

Despite the risks, these antibiotics are sometimes needed to treat what can be a life-threatening infection, says Wendi D. Jones, a pharmacist with AspenRX Health in Washington, North Carolina.

If your doctor prescribes an aminoglycoside, your health care provider should do concurrent blood testing to ensure the drug levels in your blood don’t get too high, Jones says. They should also monitor you for hearing-related side effects.

3. Loop diuretics

Loop diuretics are powerful medications that are used to treat high blood pressure and fluid retention due to heart failure, liver disease or kidney disease. The most commonly used loop diuretics are Lasix (furosemide), Bumex (bumetanide) and Demadex (torsemide).  

Experts believe these medications interfere with the ionic composition of the fluids in the ear, contributing to hearing loss. Although loop diuretics can cause permanent damage if you get a large dose by injection in the hospital, in most cases, they cause only temporary hearing loss that clears up once you stop using the drug.

“Using the lowest dose that will effectively treat the condition helps prevent ototoxicity,” Curhan notes.

If you already have hearing or balance problems, you might want to ask your doctor if a different type of diuretic would be a better choice for you.

4. Some chemotherapy drugs

Platinum-based chemotherapy drugs such as cisplatin and carboplatin are used to treat many types of cancer, including lung, reproductive, head and neck cancers.

However, they can cause permanent hearing loss, tinnitus and balance problems.

Because the drugs can be lifesaving, health care providers have to balance the pros and cons when deciding about treatment. “If a patient has to have it for a life-threatening condition, you give it to them,” Lustig says.

Scientists are working to develop medications and treatment protocols to help protect hearing while a patient is being treated with the drugs.  

5. Long-term hormone therapy

Hormone therapy can be helpful for treating menopausal symptoms such as hot flashes, but a large study led by Curhan and published in the Menopause in 2017 found a strong correlation between oral hormone therapy and hearing loss. The study, which followed almost 81,000 postmenopausal women for more than 20 years, found that the longer a woman took hormone therapy (estrogen therapy or estrogen plus progestogen therapy), the greater her risk of hearing loss.

Compared to those who never took hormones, the risk of hearing loss was 15 percent higher among women who used oral hormone therapy for five to nearly 10 years and 21 percent higher among women who used the therapy for 10 years or longer, the study showed.

Based on those results, Curhan recommends that women concerned about hearing limit their use of hormone therapy to five years or less.

6. Quinine, chloroquine and hydroxychloroquine

Quinine, a therapy to prevent and treat malaria, has long been known to cause temporary hearing loss, especially if given in large doses. Quinine is also sometimes prescribed off label to treat nocturnal leg cramps.

Two similar drugs, chloroquine and hydroxychloroquine, are also used to treat malaria and are sometimes prescribed for autoimmune diseases such as Lupus. Both chloroquine and hydroxychloroquine were investigated as possible treatments for COVID-19 infection.

Although all three drugs have been linked to temporary hearing loss and tinnitus, fortunately most patients find the hearing problems go away once they stop the medication.

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