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Comparing clinical trial population representativeness to real-world populations: an external validity analysis encompassing 43 895 trials and 5 685 738 individuals across 989 unique drugs and 286 conditions in England


Introduction

Clinical prescription guidelines and regulations are derived from evidence-based medicine, which uses gold standard research evidence to inform treatment decisions for patients.

  • Masic I
  • Miokovic M
  • Muhamedagic B
Evidence based medicine – new approaches and challenges.