Differences in the epidemiology, management and outcomes of kidney disease in men and women
Ahmed, S. B., Saad, N. & Dumanski, S. M. Gender and CKD: beyond the binary. Clin. J. Am. Soc. Nephrol. 16, 141–143 (2021).
Collister, D., Krakowsky, Y., Potter, E. & Millar, A. C. Chronic kidney disease in the transgender, nonbinary, or gender diverse person. Semin. Nephrol. 42, 129–141 (2022).
KDIGO. KDIGO clinical practice guideline for acute kidney injury. Kidney Int. Suppl. 2, 1 (2012).
Lopes, J. A. & Jorge, S. The RIFLE and AKIN classifications for acute kidney injury: a critical and comprehensive review. Clin. Kidney J. 6, 8–14 (2013).
Bellomo, R. et al. Acute renal failure — definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit. Care 8, R204–R212 (2004).
Neugarten, J. & Golestaneh, L. Sex differences in acute kidney injury. Semin. Nephrol. 42, 208–218 (2022).
Neugarten, J., Sandilya, S., Singh, B. & Golestaneh, L. Sex and the risk of AKI following cardio-thoracic surgery: a meta-analysis. Clin. J. Am. Soc. Nephrol. 11, 2113–2122 (2016).
Srisawat, N. et al. Variation in risk and mortality of acute kidney injury in critically ill patients: a multicenter study. Am. J. Nephrol. 41, 81–88 (2015).
Hogue, C. W. et al. Sex differences in neurological outcomes and mortality after cardiac surgery: a Society of Thoracic Surgery national database report. Circulation 103, 2133–2137 (2001).
Edwards, F. H., Carey, J. S., Grover, F. L., Bero, J. W. & Hartz, R. S. Impact of gender on coronary bypass operative mortality. Ann. Thorac. Surg. 66, 125–131 (1998).
Thakar, C. V. et al. ARF after open-heart surgery: influence of gender and race. Am. J. Kidney Dis. 41, 742–751 (2003).
Neugarten, J. & Golestaneh, L. The effect of gender on aminoglycoside-associated nephrotoxicity. Clin. Nephrol. 86, 183–189 (2016).
Neugarten, J. & Golestaneh, L. Female sex reduces the risk of hospital-associated acute kidney injury: a meta-analysis. BMC Nephrol. 19, 314 (2018).
Neugarten, J., Golestaneh, L. & Kolhe, N. V. Sex differences in acute kidney injury requiring dialysis. BMC Nephrol. 19, 131 (2018).
Hsu, C.-N. et al. Incidence, outcomes, and risk factors of community-acquired and hospital-acquired acute kidney injury: a retrospective cohort study. Medicine 95, e3674 (2016).
Waikar, S. S., Curhan, G. C., Ayanian, J. Z. & Chertow, G. M. Race and mortality after acute renal failure. J. Am. Soc. Nephrol. 18, 2740–2748 (2007).
Loutradis, C. et al. Acute kidney injury is more common in men than women after accounting for socioeconomic status, ethnicity, alcohol intake and smoking history. Biol. Sex. Differ. 12, 30 (2021).
Garnier, F., Couchoud, C., Landais, P. & Moranne, O. Increased incidence of acute kidney injury requiring dialysis in metropolitan France. PLoS One 14, e0211541 (2019).
Kolhe, N. V., Stevens, P. E., Crowe, A. V., Lipkin, G. W. & Harrison, D. A. Case mix, outcome and activity for patients with severe acute kidney injury during the first 24 hours after admission to an adult, general critical care unit: application of predictive models from a secondary analysis of the ICNARC Case Mix Programme Database. Crit. Care 12, S2 (2008).
Ishani, A. et al. Acute kidney injury increases risk of ESRD among elderly. J. Am. Soc. Nephrol. 20, 223–228 (2009).
James, M. T. et al. Derivation and external validation of prediction models for advanced chronic kidney disease following acute kidney injury. JAMA 318, 1787–1797 (2017).
Liotta, M., Olsson, D., Sartipy, U. & Holzmann, M. J. Minimal changes in postoperative creatinine values and early and late mortality and cardiovascular events after coronary artery bypass grafting. Am. J. Cardiol. 113, 70–75 (2014).
Vallabhajosyula, S. et al. Sex disparities in acute kidney injury complicating acute myocardial infarction with cardiogenic shock. Esc. Heart Fail. 6, 874–877 (2019).
Shah, S. et al. Mortality and recovery associated with kidney failure due to acute kidney injury. Clin. J. Am. Soc. Nephrol. 15, 995–1006 (2020).
Foley, R. N. et al. End-stage renal disease attributed to acute tubular necrosis in the United States. Am. J. Nephrol. 41, 1–6 (2015).
Pannu, N., James, M., Hemmelgarn, B. & Klarenbach, S. & Alberta Kidney Disease Network. Association between AKI, recovery of renal function, and long-term outcomes after hospital discharge. Clin. J. Am. Soc. Nephrol. 8, 194–202 (2013).
Hoy, W. E. et al. Nephron number, glomerular volume, renal disease and hypertension. Curr. Opin. Nephrol. Hypertens. 17, 258–265 (2008).
Carrero, J. J., Hecking, M., Chesnaye, N. C. & Jager, K. J. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nat. Rev. Nephrol. 14, 151–164 (2018).
United States Renal Data System. 2022 USRDS Annual Data Report: epidemiology of kidney disease in the United States. https://adr.usrds.org/2021 (2022).
Mazhar, F. et al. Estimating the prevalence of chronic kidney disease while accounting for non-random testing with inverse probability weighting. Kidney Int. S0085-2538, 00971–00971 (2022).
Inker, L. A. et al. Effects of race and sex on measured GFR: the multi-ethnic study of atherosclerosis. Am. J. Kidney Dis. 68, 743–751 (2016).
Neugarten, J., Kasiske, B., Silbiger, S. R. & Nyengaard, J. R. Effects of sex on renal structure. Nephron 90, 139–144 (2002).
Wetzels, J. F. M., Kiemeney, L. A. L. M., Swinkels, D. W., Willems, H. L. & den Heijer, M. Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study. Kidney Int. 72, 632–637 (2007).
Elseviers, M. M., Verpooten, G. A., De Broe, M. E. & De Backer, G. G. Interpretation of creatinine clearance. Lancet 1, 457 (1987).
Park, J. I., Baek, H. & Jung, H. H. Prevalence of chronic kidney disease in Korea: the Korean National Health and Nutritional Examination Survey 2011–2013. J. Korean Med. Sci. 31, 915–923 (2016).
De Nicola, L. et al. Prevalence and cardiovascular risk profile of chronic kidney disease in Italy: results of the 2008–12 National Health Examination Survey. Nephrol. Dial. Transplant. 30, 806–814 (2015).
Stengel, B. et al. Epidemiology and prognostic significance of chronic kidney disease in the elderly — the Three-City prospective cohort study. Nephrol. Dial. Transpl. 26, 3286–3295 (2011).
Rothenbacher, D. et al. Prevalence and determinants of chronic kidney disease in community-dwelling elderly by various estimating equations. BMC Public. Health 12, 343 (2012).
Gambaro, G. et al. Prevalence of CKD in Northeastern Italy: results of the INCIPE study and comparison with NHANES. Clin. J. Am. Soc. Nephrol. 5, 1946–1953 (2010).
Fernandez-Fernandez, B. et al. Gender, albuminuria and chronic kidney disease progression in treated diabetic kidney disease. J. Clin. Med. 9, 1611 (2020).
Nitsch, D. et al. Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex: a meta-analysis. BMJ 346, f324 (2013).
Risk, N. C. D. Factor Collaboration (NCD-RisC). Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 387, 1513–1530 (2016).
Connelly, P. J., Currie, G. & Delles, C. Sex differences in the prevalence, outcomes and management of hypertension. Curr. Hypertens. Rep. 24, 185–192 (2022).
Briganti, E. M. et al. Smoking is associated with renal impairment and proteinuria in the normal population: the AusDiab kidney study. Australian diabetes, obesity and lifestyle study. Am. J. Kidney Dis. 40, 704–712 (2002).
Bello, A. K. et al. Quality of chronic kidney disease management in Canadian primary care. JAMA Netw. Open. 2, e1910704 (2019).
Swartling, O. et al. Sex differences in the recognition, monitoring, and management of CKD in health care: an observational cohort study. J. Am. Soc. Nephrol. 2022030373 (2022).
Rule, A. D. et al. For estimating creatinine clearance measuring muscle mass gives better results than those based on demographics. Kidney Int. 75, 1071–1078 (2009).
Kramer, H. M., Hsu, C. & Curhan, G. Need for sex-specific ACR. Am. J. Kidney Dis. 40, 435–436 (2002).
Shen, Y. et al. Diabetes mellitus as a risk factor for incident chronic kidney disease and end-stage renal disease in women compared with men: a systematic review and meta-analysis. Endocrine 55, 66–76 (2017).
Hecking, M., Hödlmoser, S., Ahmed, S. B. & Carrero, J. J. The other way around: living with chronic kidney disease from the perspective of men. Semin. Nephrol. 42, 122–128 (2022).
Fakhouri, F. et al. Management of thrombotic microangiopathy in pregnancy and postpartum: report from an international working group. Blood 136, 2103–2117 (2020).
Balofsky, A. & Fedarau, M. Renal failure in pregnancy. Crit. Care Clin. 32, 73–83 (2016).
Ferreira, R. C. et al. Pre-eclampsia is associated with later kidney chronic disease and end-stage renal disease: systematic review and meta-analysis of observational studies. Pregnancy Hypertens. 22, 71–85 (2020).
O’Shaughnessy, M. M. et al. Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey. Nephrol. Dial. Transpl. 33, 661–669 (2018).
Cattran, D. C. et al. The impact of sex in primary glomerulonephritis. Nephrol. Dial. Transplant. 23, 2247–2253 (2008).
Mohammad, A. J. An update on the epidemiology of ANCA-associated vasculitis. Rheumatology 59, iii42–iii50 (2020).
Beckwith, H., Lightstone, L. & McAdoo, S. Sex and gender in glomerular disease. Semin. Nephrol. 42, 185–196 (2022).
Hoganson, D. D., From, A. M. & Michet, C. J. ANCA vasculitis in the elderly. J. Clin. Rheumatol. 14, 78–81 (2008).
Ono, N. et al. Characteristics of MPO-ANCA-positive granulomatosis with polyangiitis: a retrospective multi-center study in Japan. Rheumatol. Int. 35, 555–559 (2015).
Ferraro, P. M., Cunha, T., da, S. & Curhan, G. C. Sex differences and the risk of kidney stones. Semin. Nephrol. 42, 230–235 (2022).
Daudon, M., Bouzidi, H. & Bazin, D. Composition and morphology of phosphate stones and their relation with etiology. Urol. Res. 38, 459–467 (2010).
Albracht, C. D., Hreha, T. N. & Hunstad, D. A. Sex effects in pyelonephritis. Pediatr. Nephrol. 36, 507–515 (2021).
Eriksen, B. O. et al. GFR in healthy aging: an individual participant data meta-analysis of iohexol clearance in European population-based cohorts. J. Am. Soc. Nephrol. 31, 1602–1615 (2020).
Toyama, T. et al. Age differences in the relationships between risk factors and loss of kidney function: a general population cohort study. BMC Nephrol. 21, 477 (2020).
Melsom, T. et al. Sex differences in age-related loss of kidney function. J. Am. Soc. Nephrol. 33, 1891–1902 (2022).
van der Burgh, A. C., Rizopoulos, D., Ikram, M. A., Hoorn, E. J. & Chaker, L. Determinants of the evolution of kidney function with age. Kidney Int. Rep. 6, 3054–3063 (2021).
Hödlmoser, S. et al. Kidney function, kidney replacement therapy, and mortality in men and women. Kidney Int. Rep. 7, 444–454 (2022).
Swartling, O. et al. CKD progression and mortality among men and women: a nationwide study in Sweden. Am. J. Kidney Dis. 78, 190–199.e1 (2021).
Neugarten, J. & Golestaneh, L. Influence of sex on the progression of chronic kidney disease. Mayo Clin. Proc. 94, 1339–1356 (2019).
Chesnaye, N. C. et al. Renal function decline in older men and women with advanced chronic kidney disease — results from the EQUAL study. Nephrol. Dial. Transplant. 36, 1656–1663 (2021).
Ricardo, A. C. et al. Sex-related disparities in CKD progression. J. Am. Soc. Nephrol. 30, 137–146 (2019).
Neugarten, J., Acharya, A. & Silbiger, S. R. Effect of gender on the progression of nondiabetic renal disease: a meta-analysis. J. Am. Soc. Nephrol. 11, 319–329 (2000).
Jafar, T. H. et al. The rate of progression of renal disease may not be slower in women compared with men: a patient-level meta-analysis. Nephrol. Dial. Transpl. 18, 2047–2053 (2003).
Morton, R. L., Turner, R. M., Howard, K., Snelling, P. & Webster, A. C. Patients who plan for conservative care rather than dialysis: a national observational study in Australia. Am. J. Kidney Dis. 59, 419–427 (2012).
Chandna, S. M. et al. Rate of decline of kidney function, modality choice, and survival in elderly patients with advanced kidney disease. Nephron 134, 64–72 (2016).
Valdivielso, J. M., Jacobs-Cachá, C. & Soler, M. J. Sex hormones and their influence on chronic kidney disease. Curr. Opin. Nephrol. Hypertens. 28, 1–9 (2019).
Hutchens, M. P., Fujiyoshi, T., Komers, R., Herson, P. S. & Anderson, S. Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am. J. Physiol. Renal Physiol. 303, F377–F385 (2012).
Stringer, K. D. et al. Gender hormones and the progression of experimental polycystic kidney disease. Kidney Int. 68, 1729–1739 (2005).
Maric, C., Sandberg, K. & Hinojosa-Laborde, C. Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17β-estradiol in the aging Dahl salt sensitive rat. J. Am. Soc. Nephrol. 15, 1546–1556 (2004).
Filler, G. et al. Is testosterone detrimental to renal function? Kidney Int. Rep. 1, 306–310 (2016).
Metcalfe, P. D. et al. Testosterone exacerbates obstructive renal injury by stimulating TNF-α production and increasing proapoptotic and profibrotic signaling. Am. J. Physiol. Endocrinol. Metab. 294, E435–E443 (2008).
Baylis, C. & Corman, B. The aging kidney: insights from experimental studies. J. Am. Soc. Nephrol. 9, 699–709 (1998).
Amiri, M. et al. Low serum testosterone levels and the incidence of chronic kidney disease among male adults: a prospective population-based study. Andrology 8, 575–582 (2020).
Lapi, F. et al. Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer. JAMA 310, 289–296 (2013).
Shoskes, D. A., Kerr, H., Askar, M., Goldfarb, D. A. & Schold, J. Low testosterone at time of transplantation is independently associated with poor patient and graft survival in male renal transplant recipients. J. Urol. 192, 1168–1171 (2014).
Li, L. et al. Low testosterone level and risk of adverse clinical events among male patients with chronic kidney disease: a systematic review and meta-analysis of cohort studies. J. Healthc. Eng. 2022, 3630429 (2022).
Monster, T. B., Janssen, W. M., de Jong, P. E. & de Jong-van den Berg, L. T. & Prevention of Renal and Vascular End Stage Disease Study Group. Oral contraceptive use and hormone replacement therapy are associated with microalbuminuria. Arch. Intern. Med. 161, 2000–2005 (2001).
Ahmed, S. B. et al. Oral estrogen therapy in postmenopausal women is associated with loss of kidney function. Kidney Int. 74, 370–376 (2008).
Ramesh, S. et al. Estradiol and mortality in women with end-stage kidney disease. Nephrol. Dial. Transpl. 35, 1965–1972 (2020).
Melamed, M. L. et al. Raloxifene, a selective estrogen receptor modulator, is renoprotective: a post-hoc analysis. Kidney Int. 79, 241–249 (2011).
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) et al. Dietary reference values for sodium. EFSA J. 17, e05778 (2019).
Coggins, C. H. et al. Differences between women and men with chronic renal disease. Nephrol. Dial. Transplant. 13, 1430–1437 (1998).
Ellam, T., Fotheringham, J. & Kawar, B. Differential scaling of glomerular filtration rate and ingested metabolic burden: implications for gender differences in chronic kidney disease outcomes. Nephrol. Dial. Transpl. 29, 1186–1194 (2014).
Nitsch, D. Is there a difference in metabolic burden between men and women? Nephrol. Dial. Transplant. 29, 1110–1112 (2014).
Verhave, J. C. et al. Cardiovascular risk factors are differently associated with urinary albumin excretion in men and women. J. Am. Soc. Nephrol. 14, 1330–1335 (2003).
Scheven, L. et al. Predictors of progression in albuminuria in the general population: results from the PREVEND cohort. PLoS One 8, e61119 (2013).
Kronborg, J. et al. Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study. Nephrol. Dial. Transplant. 23, 2818–2826 (2008).
Minutolo, R. et al. Sex differences in the progression of CKD among older patients: pooled analysis of 4 cohort studies. Am. J. Kidney Dis. 75, 30–38 (2020).
Baigent, C. et al. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials. Lancet 400, 1788–1801 (2022).
Coresh, J. et al. Chronic kidney disease awareness, prevalence, and trends among U.S. adults, 1999 to 2000. J. Am. Soc. Nephrol. 16, 180–188 (2005).
Hödlmoser, S. et al. Sex differences in chronic kidney disease awareness among US adults, 1999 to 2018. PLoS One 15, e0243431 (2020).
John, R., Webb, M., Young, A. & Stevens, P. E. Unreferred chronic kidney disease: a longitudinal study. Am. J. Kidney Dis. 43, 825–835 (2004).
Kim, L. G. et al. How do primary care doctors in England and Wales code and manage people with chronic kidney disease? Results from the National Chronic Kidney Disease Audit. Nephrol. Dial. Transplant. 33, 1373–1379 (2018).
Qiao, Y. et al. Association of albuminuria levels with the prescription of renin-angiotensin system blockade. Hypertension 76, 1762–1768 (2020).
Stengel, B. et al. Risk profile, quality of life and care of patients with moderate and advanced CKD: the French CKD-REIN Cohort Study. Nephrol. Dial. Transpl. 34, 277–286 (2019).
Lewandowski, M. J. et al. Chronic kidney disease is more prevalent among women but more men than women are under nephrological care: analysis from six outpatient clinics in Austria 2019. Wien. Klin. Wochenschr. 135, 89–96 (2022).
Hecking, M. et al. Sex-specific differences in mortality and incident dialysis in the chronic kidney disease outcomes and practice patterns study. Kidney Int. Rep. 7, 410–423 (2022).
Tong, A. et al. Nephrologists’ perspectives on gender disparities in CKD and dialysis. Kidney Int. Rep. 7, 424–435 (2022).
Watson, S., Caster, O., Rochon, P. A. & den Ruijter, H. Reported adverse drug reactions in women and men: aggregated evidence from globally collected individual case reports during half a century. eClinicalMedicine 17, 100188 (2019).
Bosi, A. et al. Use of nephrotoxic medications in adults with chronic kidney disease in Swedish and US routine care. Clin. Kidney J. 15, 442–451 (2022).
Mauvais-Jarvis, F. et al. Sex- and gender-based pharmacological response to drugs. Pharmacol. Rev. 73, 730–762 (2021).
Soldin, O. & Mattison, D. Sex differences in pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 48, 143–157 (2009).
Anderson, G. D. Gender differences in pharmacological response. Int. Rev. Neurobiol. 83, 1s–10s (2008).
Sullivan, J. C. Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1220–R1226 (2008).
Reckelhoff, J. F. Gender differences in hypertension. Curr. Opin. Nephrol. Hypertension 27, 176–181 (2018).
Rivera, F. B. et al. Sex differences in cardiovascular outcomes of SGLT-2 inhibitors in heart failure randomized controlled trials: a systematic review and meta-analysis. Am. Heart J. 26, 100261 (2023).
Singh, A. K. & Singh, R. Gender difference in cardiovascular outcomes with SGLT-2 inhibitors and GLP-1 receptor agonist in type 2 diabetes: a systematic review and meta-analysis of cardio-vascular outcome trials. Diabetes Metab. Syndr. 14, 181–187 (2020).
Astley, M. E. et al. The ERA Registry annual report 2020: a summary. Clin. Kidney J. 16, 1330–1354 (2023).
Australia and New Zealand Dialysis and Transplant Registry. ANZDATA Registry. 44th Report, Chapter 1: Incidence of Kidney Failure with Replacement Therapy. http://www.anzdata.org.au (2021).
Antlanger, M. et al. Sex differences in kidney replacement therapy initiation and maintenance. Clin. J. Am. Soc. Nephrol. 14, 1616–1625 (2019).
Astley, M. E. et al. The ERA registry annual report 2020: a summary. Clin. Kidney J. 168, 1330–1354 (2023).
Kramer, A. et al. The European Renal Association — European Dialysis and Transplant Association (ERA-EDTA) registry annual report 2016: a summary. Clin. Kidney J. 12, 702–720 (2019).
United States Renal Data System. 2021 USRDS Annual Data Report: Epidemiology of kidney disease in the United States. https://adr.usrds.org/2021 (2021).
Hecking, M. et al. Sex-specific differences in hemodialysis prevalence and practices and the male-to-female mortality rate: the Dialysis Outcomes and Practice Patterns Study (DOPPS). PLoS Med. 11, e1001750 (2014).
Sparke, C. et al. Estimating the total incidence of kidney failure in Australia including individuals who are not treated by dialysis or transplantation. Am. J. Kidney Dis. 61, 413–419 (2013).
Wang, Z.-F. et al. Effect of marital status on depression and mortality among patients with chronic kidney disease from national health and nutrition examination survey 2005–2014. Kidney Dis. 7, 391–400 (2021).
Daugirdas, J. T. et al. Surface-area-normalized Kt/V: a method of rescaling dialysis dose to body surface area-implications for different-size patients by gender. Semin. Dial. 21, 415–421 (2008).
Spalding, E. M., Chandna, S. M., Davenport, A. & Farrington, K. Kt/V underestimates the hemodialysis dose in women and small men. Kidney Int. 74, 348–355 (2008).
Miller, C. D., Robbin, M. L. & Allon, M. Gender differences in outcomes of arteriovenous fistulas in hemodialysis patients. Kidney Int. 63, 346–352 (2003).
Wasse, H., Hopson, S. D. & McClellan, W. Racial and gender differences in arteriovenous fistula use among incident hemodialysis patients. Am. J. Nephrol. 32, 234–241 (2010).
Caplin, N., Sedlacek, M., Teodorescu, V., Falk, A. & Uribarri, J. Venous access: women are equal. Am. J. Kidney Dis. 41, 429–432 (2003).
Ferrucci, L. et al. Low testosterone levels and the risk of anemia in older men and women. Arch. Intern. Med. 166, 1380–1388 (2006).
Locatelli, F. et al. Clinical practice guidelines for anemia in chronic kidney disease: problems and solutions. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int. 74, 1237–1240 (2008).
Ifudu, O. Patient characteristics determining rHuEPO dose requirements. Nephrol. Dial. Transpl. 17, 38–41 (2002).
Hsu, C. Y., Bates, D. W., Kuperman, G. J. & Curhan, G. C. Relationship between hematocrit and renal function in men and women. Kidney Int. 59, 725–731 (2001).
Hsu, C.-Y., McCulloch, C. E. & Curhan, G. C. Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. J. Am. Soc. Nephrol. 13, 504–510 (2002).
Frankenfield, D. L. et al. Racial/ethnic analysis of selected intermediate outcomes for hemodialysis patients: results from the 1997 ESRD Core Indicators Project. Am. J. Kidney Dis. 34, 721–730 (1999).
Madore, F. et al. Anemia in hemodialysis patients: variables affecting this outcome predictor. J. Am. Soc. Nephrol. 8, 1921–1929 (1997).
Ifudu, O. et al. Gender modulates responsiveness to recombinant erythropoietin. Am. J. Kidney Dis. 38, 518–522 (2001).
Park, C. et al. A scoping review of inequities in access to organ transplant in the United States. Int. J. Equity Health 21, 22 (2022).
Hödlmoser, S. et al. Sex differences in kidney transplantation: Austria and the United States, 1978–2018. Front. Med. 8, 800933 (2022).
Melk, A., Schmidt, B. M. W., Geyer, S. & Epping, J. Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease — a population based analysis. PLoS One 15, e0241556 (2020).
Sypek, M. P. et al. Access to waitlisting for deceased donor kidney transplantation in Australia. Nephrology 24, 758–766 (2019).
Ladhani, M., Craig, J. C. & Wong, G. Obesity and gender-biased access to deceased donor kidney transplantation. Nephrol. Dial. Transpl. 35, 184–189 (2020).
Schold, J. D. et al. Barriers to evaluation and wait listing for kidney transplantation. Clin. J. Am. Soc. Nephrol. 6, 1760–1767 (2011).
Cozzi, E. et al. An analysis by the European Committee on Organ Transplantation of the Council of Europe outlining the international landscape of donors and recipients sex in solid organ transplantation. Transpl. Int. 35, 10322 (2022).
Procaccio, F. et al. Deaths with acute cerebral lesions in ICU: does the number of potential organ donors depend on predictable factors? Minerva Anestesiol. 81, 636–644 (2015).
Austria’s digital government agency. Organ transplantation. https://www.oesterreich.gv.at/en/themen/gesundheit_und_notfaelle/organtransplantation.html (2023).
Kurnikowski, A. et al. Country-specific sex disparities in living kidney donation. Nephrol. Dial. Transpl. 37, 595–598 (2022).
AlHejaili, W. et al. Scores of awareness and altruism in organ transplantation among Saudi health colleges students-impact of gender, year of study, and field of specialization. Saudi J. Kidney Dis. Transpl. 29, 1028–1034 (2018).
Zeiler, K. Just love in live organ donation. Med. Health Care Philos. 12, 323–331 (2009).
Gill, J. et al. The change in living kidney donation in women and men in the United States (2005-2015): a population-based analysis. J. Am. Soc. Nephrol. 29, 1301–1308 (2018).
Rudge, C., Matesanz, R., Delmonico, F. L. & Chapman, J. International practices of organ donation. Br. J. Anaesth. 108, i48–i55 (2012).
Boenink, R. et al. The ERA Registry annual report 2019: summary and age comparisons. Clin. Kidney J. 15, 452–472 (2021).
Katz-Greenberg, G. & Shah, S. Sex and gender differences in kidney transplantation. Semin. Nephrol. 42, 219–229 (2022).
Lepeytre, F. et al. Association of sex with risk of kidney graft failure differs by age. J. Am. Soc. Nephrol. 28, 3014–3023 (2017).
Vinson, A. J. et al. Age-dependent sex differences in graft loss after kidney transplantation. Transplantation 106, 1473–1484 (2022).
Denhaerynck, K. et al. Prevalence and risk factors of non-adherence with immunosuppressive medication in kidney transplant patients. Am. J. Transpl. 7, 108–116 (2007).
Kiley, D. J., Lam, C. S. & Pollak, R. A study of treatment compliance following kidney transplantation. Transplantation 55, 51–56 (1993).
Bellini, M. I., Nozdrin, M., Pengel, L., Knight, S. & Papalois, V. The impact of recipient demographics on outcomes from living donor kidneys: systematic review and meta-analysis. J. Clin. Med. 10, 5556 (2021).
Vinson, A. J. et al. A multinational cohort study uncovered sex differences in excess mortality after kidney transplant. Kidney Int. 103, 1131–1143 (2023).
Barsky, A. J., Peekna, H. M. & Borus, J. F. Somatic symptom reporting in women and men. J. Gen. Intern. Med. 16, 266–275 (2001).
Fryback, D. G. et al. US norms for six generic health-related quality-of-life indexes from the National Health Measurement study. Med. Care 45, 1162–1170 (2007).
Vigneshwaran, E., Padmanabhareddy, Y., Devanna, N. & Alvarez-Uria, G. Gender differences in health related quality of life of people living with HIV/AIDS in the era of highly active antiretroviral therapy. N. Am. J. Med. Sci. 5, 102–107 (2013).
Overbeck, I. et al. Changes in quality of life after renal transplantation. Transplant. Proc. 37, 1618–1621 (2005).
Fiebiger, W., Mitterbauer, C. & Oberbauer, R. Health-related quality of life outcomes after kidney transplantation. Health Qual. Life Outcomes 2, 2 (2004).
von der Lippe, N., Waldum, B., Østhus, T.-B. H., Reisæter, A. V. & Os, I. Health related quality of life in patients in dialysis after renal graft loss and effect of gender. BMC Women’s Health 14, 34 (2014).
Chesnaye, N. C. et al. Health-related quality-of-life trajectories over time in older men and women with advanced chronic kidney disease. Clin. J. Am. Soc. Nephrol. 17, 205–214 (2022).
de Rooij, E. N. M. et al. Quality of life before and after the start of dialysis in older patients. Clin. J. Am. Soc. Nephrol. 17, 1159–1167 (2022).
Gemmell, L. A. et al. Gender and racial differences in stress, coping, and health-related quality of life in chronic kidney disease. J. Pain. Symptom Manag. 52, 806–812 (2016).
Yeh, S.-C. J. & Chou, H.-C. Coping strategies and stressors in patients with hemodialysis. Psychosom. Med. 69, 182–190 (2007).
Yeh, S.-C. J., Huang, C.-H., Chou, H.-C. & Wan, T. T. H. Gender differences in stress and coping among elderly patients on hemodialysis. Sex. Roles 60, 44 (2008).
Courtenay, W. H. Constructions of masculinity and their influence on men’s well-being: a theory of gender and health. Soc. Sci. Med. 50, 1385–1401 (2000).
Rooij et al. Symptom burden before and after dialysis initiation in older patients. Clin. J. Am. Soc. Nephrol. 17, 1719–1729 (2022).
van de Luijtgaarden, M. W. M. et al. Uraemic symptom burden and clinical condition in women and men of ≥65 years of age with advanced chronic kidney disease: results from the EQUAL study. Nephrol. Dial. Transplant. 34, 1189–1196 (2019).
McLean, C. P., Asnaani, A., Litz, B. T. & Hofmann, S. G. Gender differences in anxiety disorders: prevalence, course of illness, comorbidity and burden of illness. J. Psychiatr. Res. 45, 1027–1035 (2011).
Lopes, G. B. et al. Depression as a potential explanation for gender differences in health-related quality of life among patients on maintenance hemodialysis. Nephron Clin. Pract. 115, 35–40 (2010).
Kim, M. H., Johnston, S. S., Chu, B.-C., Dalal, M. R. & Schulman, K. L. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States. Circ. Cardiovasc. Qual. Outcomes 4, 313–320 (2011).
Chugh, S. S. et al. Worldwide epidemiology of atrial fibrillation. Circulation 129, 837–847 (2014).
Shajahan, S., Amin, J., Phillips, J. K. & Hildreth, C. M. Relationship between sex and cardiovascular mortality in chronic kidney disease: a systematic review and meta-analysis. PLoS One 16, e0254554 (2021).
Jung, C.-Y. et al. Sex disparities and adverse cardiovascular and kidney outcomes in patients with chronic kidney disease: results from the KNOW-CKD. Clin. Res. Cardiol. 110, 1116–1127 (2021).
Foster, B. J., Mitsnefes, M. M., Dahhou, M., Zhang, X. & Laskin, B. L. Changes in excess mortality from end stage renal disease in the United States from 1995 to 2013. Clin. J. Am. Soc. Nephrol. 13, 91–99 (2018).
Vogelzang, J. L. et al. Mortality from infections and malignancies in patients treated with renal replacement therapy: data from the ERA-EDTA registry. Nephrol. Dial. Transpl. 30, 1028–1037 (2015).
Carrero, J. J. et al. Cardiovascular and noncardiovascular mortality among men and women starting dialysis. Clin. J. Am. Soc. Nephrol. 6, 1722–1730 (2011).
Lim, W. H. et al. Sex disparity in cause-specific and all-cause mortality among incident dialysis patients. Am. J. Kidney Dis. 81, 156–167.e1 (2023).
Ros, S. et al. Increased risk of fatal infections in women starting peritoneal dialysis. Perit. Dial. Int. 33, 487–494 (2013).
Jassal, S. V. et al. International variation in dialysis discontinuation in patients with advanced kidney disease. CMAJ 192, E995–E1002 (2020).
van Oevelen, M. et al. Dialysis withdrawal in The Netherlands between 2000 and 2019: time trends, risk factors and centre variation. Nephrol. Dial. Transpl. 36, 2112–2119 (2021).
Ocak, G. et al. Mortality due to bleeding, myocardial infarction and stroke in dialysis patients. J. Thromb. Haemost. 16, 1953–1963 (2018).
Kainz, A. et al. Sex-specific analysis of haemodialysis prevalence, practices and mortality over time: the Austrian Dialysis Registry from 1965 to 2014. Nephrol. Dial. Transplant. 34, 1026–1035 (2019).
De La Mata, N. L. et al. Sex differences in mortality among binational cohort of people with chronic kidney disease: population based data linkage study. BMJ 375, e068247 (2021).
Ceretta, M. L. et al. Changes in co-morbidity pattern in patients starting renal replacement therapy in Europe — data from the ERA-EDTA Registry. Nephrol. Dial. Transpl. 33, 1794–1804 (2018).
Roth, G. A. et al. Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J. Am. Coll. Cardiol. 76, 2982–3021 (2020).
Zhang, J., Jin, Y., Jia, P., Li, N. & Zheng, Z.-J. Global gender disparities in premature death from cardiovascular disease, and their associations with country capacity for noncommunicable disease prevention and control. Int. J. Env. Res. Public. Health 18, 10389 (2021).
Woodward, M. Cardiovascular disease and the female disadvantage. Int. J. Env. Res. Public. Health 16, 1165 (2019).
Vogel, B. et al. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. Lancet 397, 2385–2438 (2021).
Soliman, E. Z. et al. Chronic kidney disease and prevalent atrial fibrillation: the Chronic Renal Insufficiency Cohort (CRIC). Am. Heart J. 159, 1102–1107 (2010).
Baber, U. et al. Association of chronic kidney disease with atrial fibrillation among adults in the United States: Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. Circ. Arrhythm. Electrophysiol. 4, 26–32 (2011).
Thompson, S. et al. Cause of death in patients with reduced kidney function. J. Am. Soc. Nephrol. 26, 2504–2511 (2015).
Toth-Manikowski, S. M. et al. Sex differences in cardiovascular outcomes in CKD: findings from the CRIC study. Am. J. Kidney Dis. 78, 200–209.e1 (2021).
Currie, C. J. et al. Major adverse cardiovascular events in people with chronic kidney disease in relation to disease severity and diabetes status. PLoS One 14, e0221044 (2019).
Nagai, K., Asahi, K., Iseki, K. & Yamagata, K. Estimating the prevalence of definitive chronic kidney disease in the Japanese general population. Clin. Exp. Nephrol. 25, 885–892 (2021).
Moţa, E. et al. Prevalence of chronic kidney disease and its association with cardio-metabolic risk factors in the adult Romanian population: the PREDATORR study. Int. Urol. Nephrol. 47, 1831–1838 (2015).
Bongard, V. et al. Estimation et caractérisation de l’insuffisance rénale chronique en France. Annales de. Cardiologie et. d’Angéiologie 61, 239–244 (2012).
NHS. Health Survey for England. NHS Digital. https://digital.nhs.uk/data-and-information/publications/statistical/health-survey-for-england/health-survey-for-england-2016 (2016).
Murphy, D. et al. Trends in prevalence of chronic kidney disease in the United States. Ann. Intern. Med. 165, 473–481 (2016).
Otero, A., de Francisco, A., Gayoso, P. & García, F., EPIRCE Study Group. Prevalence of chronic renal disease in Spain: results of the EPIRCE study. Nefrologia 30, 78–86 (2010).
Cirillo, M. et al. Low glomerular filtration in the population: prevalence, associated disorders, and awareness. Kidney Int. 70, 800–806 (2006).
Zdrojewski et al. Prevalence of chronic kidney disease in a representative sample of the Polish population: results of the NATPOL 2011 survey. Nephrol. Dial. Transpl. 31, 433–439 (2016).
Gasparini, A. et al. Prevalence and recognition of chronic kidney disease in Stockholm healthcare. Nephrol. Dial. Transpl. 31, 2086–2094 (2016).
Vinhas, J. et al. Prevalence of chronic kidney disease and associated risk factors, and risk of end-stage renal disease: data from the PREVADIAB study. Nephron Clin. Pract. 119, c35–c40 (2011).
Chronic kidney disease: Australian facts, How many people are living with chronic kidney disease in Australia? Australian Institute of Health and Welfare https://www.aihw.gov.au/reports/chronic-kidney-disease/chronic-kidney-disease/contents/how-many-people-are-living-with-chronic-kidney-dis (2023).
Epidemiology and disease control division, Ministry of Health, Singapore. National Health Survey https://www.moh.gov.sg/resources-statistics/reports/national-health-survey-2010 (2010).
Arora, P. et al. Prevalence estimates of chronic kidney disease in Canada: results of a nationally representative survey. CMAJ 185, E417–E423 (2013).
Juutilainen, A. et al. Trends in estimated kidney function: the FINRISK surveys. Eur. J. Epidemiol. 27, 305–313 (2012).
Zhang, L. et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet 379, 815–822 (2012).