Wegovy, Mounjaro and the future of weight loss drugs


On this version of Hot off the Wire:

A new large study finds that the popular weight-loss drug Wegovy reduced the risk of serious heart problems by 20% in certain patients. The international trial showed the weekly injections prevented heart attacks, strokes and heart-related deaths. Wegovy is a high-dose version of the diabetes treatment Ozempic. The latest study tested Wegovy in people without the disease. It’s being praised as a landmark study that could change the way doctors treat heart disease in some patients. The findings could also shift perceptions that a new class of obesity drugs are cosmetic treatments and put pressure on insurers to cover them.

Federal regulators say a new version of the popular diabetes treatment Mounjaro can be sold as a weight-loss drug. The Food and Drug Administration approved drug named Zepbound on Wednesday. The drug has been shown to help dieters lose 40 to 60 pounds in testing. It is the latest diabetes drug approved for weight loss, joining Novo Nordisk’s Wegovy, a high-dose version of Ozempic. Short supply and high costs have limited access to both medications. The FDA approved the new drug for people considered obese or for those who are overweight and have a weight-related health condition.

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According to a new study from the drugmaker behind Wegovy, a popular drug for weight loss, Wegovy can reduce the risk of heart attack, stroke, or heart-related death by 20%. CBS News Bay Area anchor Ryan Yamamoto talks to Sun Kim, MD, associate professor of medicine at Stanford, about how the drug seems to help the heart, who could benefit from this, and if there are any potential side effects



A new report says progress against childhood cancers has stalled in recent years for Black and Hispanic youth. Thursday’s report from the Centers for Disease Control and Prevention looked at cancer death rates for children and teens over two decades. The rates for white, Hispanic and Black children started about the same and all went down during the first decade. But then over the next 10 years, only the rate for white children dipped a little lower. Overall, the cancer death rate for children and teenagers declined 24% over the two decades, with the biggest drop in deaths from leukemia.

NEW YORK (AP) — Syphilis cases in U.S. newborns again are on the rise. It has health officials calling for new measures to stop the increase, including encouraging millions of sexually active women of childbearing age and their partners to get tested. The Centers for Disease Control and Prevention says more than 3,700 babies were born with congenital syphilis in 2022. That’s 10 times more than a decade ago and a 32% increase from 2021. CDC officials say there needs to be expanded testing. The agency also suggests starting syphilis treatment as soon as a pregnant woman tests positive.

Losing after you hit 60 can feel almost improbable, as when you get older, your body becomes less efficient and your metabolism slows. However, it isn’t time to give up just yet, as there are things you can do to lose weight,



LONDON (AP) — Britain’s medicines regulator has authorized the world’s first gene therapy treatment for sickle cell disease, in a move that could offer relief to thousands of people with the crippling illness in the U.K. In a statement on Thursday, the Medicines and Healthcare Regulatory Agency said it had approved Casgevy, the first medicine licensed using the gene editing tool CRISPR, which won its makers a Nobel prize in 2020. The medicine was approved for patients with sickle cell and thalassemia. Both diseases are caused by mistakes in the genes that carry hemoglobin, the protein in red blood cells that carry oxygen.

It’s very important to make sure we’re eating enough protein every day, regardless of whether you’re a bodybuilder or not. The recommended daily intake can fall between 50g to 175g, with high protein diets promoting muscle growth and weight loss. The first tip involves snacking smarter. Instead of grabbing a chocolate bar, perhaps a protein yoghurt is a better option. Secondly, try implementing eggs into your diet by swapping them with your morning muffin, as they are high in protein and are versatile. Another tip is to pick Greek yoghurt over regular yoghurt, as it is made by removing whey, creating a protein-rich yoghurt. You should also think about protein first for every meal, as you want to make sure each meal has enough protein in it. Lastly, trying more canned fish will benefit your protein intake, as one can pack 20g while also offering essential omega-3 fatty acids.





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